Antileukoproteinase (SLPI)
Homo sapiens — UniProt P03973
Data last refreshed: (UniProt release unknown)
Key facts
Antileukoproteinase (SLPI) is a protein from Homo sapiens identified by UniProt accession P03973, 132 residues long. MolForge cross-references it against 0 known binders and 310 disease associations.
- UniProt accession: P03973; gene symbol SLPI.
- Organism: Homo sapiens.
- Length: 132 amino acids.
- Top disease associations (Open Targets): acute myeloid leukemia, neoplasm and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Antileukoproteinase |
|---|---|
| UniProt accession | P03973 |
| Gene | SLPI |
| Organism | Homo sapiens |
| Length | 132 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (310)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.12
- neoplasm · score 0.11
- head and neck squamous cell carcinoma · score 0.09
- hepatocellular carcinoma · score 0.09
- infection · score 0.08
- infect · score 0.08
- experimental autoimmune encephalomyelitis · score 0.08
- bacterial urinary tract infection · score 0.08
- Immunodeficiency due to a late component of complements deficiency · score 0.07
- psoriasis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P03973-F1 | alphafold | PREDICTED | 85.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P03973.
Amino-acid sequence (132 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLPI?
The strongest Open Targets associations for SLPI are acute myeloid leukemia, neoplasm, head and neck squamous cell carcinoma, hepatocellular carcinoma and infection.
How long is the SLPI protein?
The Homo sapiens SLPI protein (UniProt P03973) is 132 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P03973 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P03973 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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