Superoxide dismutase [Mn], mitochondrial (SOD2)
Homo sapiens — UniProt P04179
Data last refreshed: (UniProt release unknown)
Key facts
Superoxide dismutase [Mn], mitochondrial (SOD2) is a protein from Homo sapiens identified by UniProt accession P04179, 222 residues long. MolForge cross-references it against 1 known binders and 916 disease associations.
- UniProt accession: P04179; gene symbol SOD2.
- Organism: Homo sapiens.
- Length: 222 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, diabetic nephropathy and diabetic retinopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Superoxide dismutase [Mn], mitochondrial |
|---|---|
| UniProt accession | P04179 |
| Gene | SOD2 |
| Organism | Homo sapiens |
| Length | 222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (916)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- diabetic nephropathy · score 0.42
- diabetic retinopathy · score 0.19
- neoplasm · score 0.11
- cancer · score 0.10
- chronic kidney disease · score 0.10
- breast cancer · score 0.10
- type 2 diabetes mellitus · score 0.09
- age-related macular degeneration · score 0.09
- coronary artery disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P04179-F1 | alphafold | PREDICTED | 93.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P04179.
Amino-acid sequence (222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOD2?
The strongest Open Targets associations for SOD2 are neurodegenerative disease, diabetic nephropathy, diabetic retinopathy, neoplasm and cancer.
How long is the SOD2 protein?
The Homo sapiens SOD2 protein (UniProt P04179) is 222 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P04179 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P04179 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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