Transcription factor Sp1 (SP1)
Homo sapiens — UniProt P08047
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Sp1 (SP1) is a protein from Homo sapiens identified by UniProt accession P08047, 785 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.
- UniProt accession: P08047; gene symbol SP1.
- Organism: Homo sapiens.
- Length: 785 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, severe acute respiratory syndrome and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Sp1 |
|---|---|
| UniProt accession | P08047 |
| Gene | SP1 |
| Organism | Homo sapiens |
| Length | 785 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (209)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- severe acute respiratory syndrome · score 0.37
- neuroinflammatory disorder · score 0.37
- mean corpuscular volume · score 0.27
- erythrocyte count · score 0.27
- glioblastoma multiforme · score 0.25
- mean corpuscular hemoglobin concentration · score 0.25
- breast adenocarcinoma · score 0.25
- mean corpuscular hemoglobin · score 0.24
- sex hormone-binding globulin measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P08047-F1 | alphafold | PREDICTED | 39.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P08047.
Amino-acid sequence (785 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP1?
The strongest Open Targets associations for SP1 are neurodegenerative disease, severe acute respiratory syndrome, neuroinflammatory disorder, mean corpuscular volume and erythrocyte count.
How long is the SP1 protein?
The Homo sapiens SP1 protein (UniProt P08047) is 785 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P08047 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P08047 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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