Extracellular superoxide dismutase [Cu-Zn] (SOD3)
Homo sapiens — UniProt P08294
Data last refreshed: (UniProt release unknown)
Key facts
Extracellular superoxide dismutase [Cu-Zn] (SOD3) is a protein from Homo sapiens identified by UniProt accession P08294, 240 residues long. MolForge cross-references it against 0 known binders and 340 disease associations.
- UniProt accession: P08294; gene symbol SOD3.
- Organism: Homo sapiens.
- Length: 240 amino acids.
- Top disease associations (Open Targets): blood protein measurement, creatinine measurement and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Extracellular superoxide dismutase [Cu-Zn] |
|---|---|
| UniProt accession | P08294 |
| Gene | SOD3 |
| Organism | Homo sapiens |
| Length | 240 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (340)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.49
- creatinine measurement · score 0.43
- neoplasm · score 0.11
- chronic obstructive pulmonary disease · score 0.09
- papillary thyroid carcinoma · score 0.08
- lung cancer · score 0.08
- Cough · score 0.08
- osteoarthritis · score 0.07
- cancer · score 0.07
- type 1 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P08294-F1 | alphafold | PREDICTED | 88.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P08294.
Amino-acid sequence (240 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOD3?
The strongest Open Targets associations for SOD3 are blood protein measurement, creatinine measurement, neoplasm, chronic obstructive pulmonary disease and papillary thyroid carcinoma.
How long is the SOD3 protein?
The Homo sapiens SOD3 protein (UniProt P08294) is 240 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P08294 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P08294 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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