U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70)
Homo sapiens — UniProt P08621
Data last refreshed: (UniProt release unknown)
Key facts
U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) is a protein from Homo sapiens identified by UniProt accession P08621, 437 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: P08621; gene symbol SNRNP70.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, systolic blood pressure and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | U1 small nuclear ribonucleoprotein 70 kDa |
|---|---|
| UniProt accession | P08621 |
| Gene | SNRNP70 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- systolic blood pressure · score 0.17
- diastolic blood pressure · score 0.15
- pulse pressure measurement · score 0.12
- mean arterial pressure · score 0.11
- Global developmental delay · score 0.11
- Systemic lupus erythematosus · score 0.09
- hepatocellular carcinoma · score 0.08
- mixed connective tissue disease · score 0.05
- cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P08621-F1 | alphafold | PREDICTED | 71.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P08621.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNRNP70?
The strongest Open Targets associations for SNRNP70 are neurodegenerative disease, systolic blood pressure, diastolic blood pressure, pulse pressure measurement and mean arterial pressure.
How long is the SNRNP70 protein?
The Homo sapiens SNRNP70 protein (UniProt P08621) is 437 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P08621 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P08621 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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