About Interleukin-6 receptor subunit alpha
Interleukin-6 receptor subunit alpha (IL6R) is a protein
from Homo sapiens identified by UniProt accession
P08887, 468 residues long.
MolForge cross-references it against 0 known binders and
847 disease associations.
Target properties
| Protein name | Interleukin-6 receptor subunit alpha |
|---|
| UniProt accession | P08887 |
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| Gene | IL6R |
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| Organism | Homo sapiens |
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| Length | 468 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (847)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.70
- juvenile idiopathic arthritis · score 0.58
- COVID-19 · score 0.57
- temporal arteritis · score 0.56
- neuromyelitis optica · score 0.56
- atopic eczema · score 0.55
- Eczematoid dermatitis · score 0.55
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.53
- immune system disease · score 0.51
- systemic scleroderma · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08887-F1 | alphafold | PREDICTED | 77.91 | — |
Amino-acid sequence (468 residues)
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR
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