High mobility group protein B1 (HMGB1)

About High mobility group protein B1

High mobility group protein B1 (HMGB1) is a protein from Homo sapiens identified by UniProt accession P09429, 215 residues long. MolForge cross-references it against 0 known binders and 1,129 disease associations.

Target properties

Protein name	High mobility group protein B1
UniProt accession	P09429
Gene	HMGB1
Organism	Homo sapiens
Length	215 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1129)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.49
mean corpuscular volume · score 0.49
mean corpuscular hemoglobin concentration · score 0.46
mean corpuscular hemoglobin · score 0.45
brachyphalangy, polydactyly, and tibial aplasia/hypoplasia · score 0.42
eosinophil percentage of leukocytes · score 0.40
erythrocyte count · score 0.39
inborn error of immunity · score 0.37
neurodegenerative disease · score 0.35
body mass index · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P09429-F1	alphafold	PREDICTED	76.84	—

Amino-acid sequence (215 residues)

MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards