SPARC (SPARC)
Homo sapiens — UniProt P09486
Data last refreshed: (UniProt release unknown)
Key facts
SPARC (SPARC) is a protein from Homo sapiens identified by UniProt accession P09486, 303 residues long. MolForge cross-references it against 0 known binders and 763 disease associations.
- UniProt accession: P09486; gene symbol SPARC.
- Organism: Homo sapiens.
- Length: 303 amino acids.
- Top disease associations (Open Targets): osteogenesis imperfecta, neurodegenerative disease and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPARC |
|---|---|
| UniProt accession | P09486 |
| Gene | SPARC |
| Organism | Homo sapiens |
| Length | 303 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (763)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta · score 0.57
- neurodegenerative disease · score 0.44
- body mass index · score 0.40
- osteogenesis imperfecta type 4 · score 0.37
- body height · score 0.32
- Myocardial Ischemia · score 0.24
- ovarian cancer · score 0.20
- lung adenocarcinoma · score 0.20
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P09486-F1 | alphafold | PREDICTED | 84.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P09486.
Amino-acid sequence (303 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPARC?
The strongest Open Targets associations for SPARC are osteogenesis imperfecta, neurodegenerative disease, body mass index, osteogenesis imperfecta type 4 and body height.
How long is the SPARC protein?
The Homo sapiens SPARC protein (UniProt P09486) is 303 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P09486 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P09486 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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