About Histone H2A-Bbd type 1
Histone H2A-Bbd type 1 (H2AB1) is a protein
from Homo sapiens identified by UniProt accession
P0C5Y9, 115 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Histone H2A-Bbd type 1 |
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| UniProt accession | P0C5Y9 |
|---|
| Gene | H2AB1 |
|---|
| Organism | Homo sapiens |
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| Length | 115 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (15)
Diseases linked to this target (Open Targets).
- cancer · score 0.37
- breast carcinoma · score 0.37
- melanoma · score 0.37
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
- congenital lethal erythroderma · score 0.04
- Hereditary persistence of alpha-fetoprotein · score 0.04
- gastric mucosal hypertrophy · score 0.04
- Congenital deficiency in alpha-fetoprotein · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C5Y9-F1 | alphafold | PREDICTED | 87.63 | — |
Amino-acid sequence (115 residues)
MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI EYLTAKVPEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED
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