Histone H2A-Bbd type 1 (H2AB1)
Homo sapiens — UniProt P0C5Y9
Data last refreshed: (UniProt release unknown)
Key facts
Histone H2A-Bbd type 1 (H2AB1) is a protein from Homo sapiens identified by UniProt accession P0C5Y9, 115 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: P0C5Y9; gene symbol H2AB1.
- Organism: Homo sapiens.
- Length: 115 amino acids.
- Top disease associations (Open Targets): cancer, breast carcinoma and melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone H2A-Bbd type 1 |
|---|---|
| UniProt accession | P0C5Y9 |
| Gene | H2AB1 |
| Organism | Homo sapiens |
| Length | 115 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- cancer · score 0.37
- breast carcinoma · score 0.37
- melanoma · score 0.37
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
- congenital lethal erythroderma · score 0.04
- Hereditary persistence of alpha-fetoprotein · score 0.04
- gastric mucosal hypertrophy · score 0.04
- Congenital deficiency in alpha-fetoprotein · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0C5Y9-F1 | alphafold | PREDICTED | 87.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0C5Y9.
Amino-acid sequence (115 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with H2AB1?
The strongest Open Targets associations for H2AB1 are cancer, breast carcinoma, melanoma, plasma fibronectin deficiency and isolated asymptomatic elevation of creatine phosphokinase.
How long is the H2AB1 protein?
The Homo sapiens H2AB1 protein (UniProt P0C5Y9) is 115 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0C5Y9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0C5Y9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.