Serine protease inhibitor Kazal-type 8 (SPINK8)
Homo sapiens — UniProt P0C7L1
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 8 (SPINK8) is a protein from Homo sapiens identified by UniProt accession P0C7L1, 97 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: P0C7L1; gene symbol SPINK8.
- Organism: Homo sapiens.
- Length: 97 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, blood protein measurement and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 8 |
|---|---|
| UniProt accession | P0C7L1 |
| Gene | SPINK8 |
| Organism | Homo sapiens |
| Length | 97 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.28
- blood protein measurement · score 0.22
- systolic blood pressure · score 0.17
- Diuretic use measurement · score 0.13
- Beta blocking agent use measurement · score 0.11
- coronary artery disease · score 0.11
- body weight · score 0.09
- emotional symptom measurement · score 0.09
- Agents acting on the renin-angiotensin system use measurement · score 0.09
- urate measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0C7L1-F1 | alphafold | PREDICTED | 80.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0C7L1.
Amino-acid sequence (97 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK8?
The strongest Open Targets associations for SPINK8 are diastolic blood pressure, blood protein measurement, systolic blood pressure, Diuretic use measurement and Beta blocking agent use measurement.
How long is the SPINK8 protein?
The Homo sapiens SPINK8 protein (UniProt P0C7L1) is 97 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0C7L1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0C7L1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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