Protein SLFN14 (SLFN14)
Homo sapiens — UniProt P0C7P3
Data last refreshed: (UniProt release unknown)
Key facts
Protein SLFN14 (SLFN14) is a protein from Homo sapiens identified by UniProt accession P0C7P3, 912 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.
- UniProt accession: P0C7P3; gene symbol SLFN14.
- Organism: Homo sapiens.
- Length: 912 amino acids.
- Top disease associations (Open Targets): Rare hemorrhagic disorder due to a constitutional platelet anomaly, platelet component distribution width and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein SLFN14 |
|---|---|
| UniProt accession | P0C7P3 |
| Gene | SLFN14 |
| Organism | Homo sapiens |
| Length | 912 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (244)
Diseases linked to this target (Open Targets).
- Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.73
- platelet component distribution width · score 0.51
- mean platelet volume · score 0.48
- reticulocyte count · score 0.48
- Thrombocytopenia · score 0.45
- Abnormal bleeding · score 0.44
- platelet count · score 0.42
- neurodegenerative disease · score 0.42
- Red cell distribution width · score 0.39
- blood platelet disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0C7P3-F1 | alphafold | PREDICTED | 83.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0C7P3.
Amino-acid sequence (912 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLFN14?
The strongest Open Targets associations for SLFN14 are Rare hemorrhagic disorder due to a constitutional platelet anomaly, platelet component distribution width, mean platelet volume, reticulocyte count and Thrombocytopenia.
How long is the SLFN14 protein?
The Homo sapiens SLFN14 protein (UniProt P0C7P3) is 912 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0C7P3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0C7P3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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