Putative inactive neutral ceramidase B (ASAH2B)
Homo sapiens — UniProt P0C7U1
Data last refreshed: (UniProt release unknown)
Key facts
Putative inactive neutral ceramidase B (ASAH2B) is a protein from Homo sapiens identified by UniProt accession P0C7U1, 165 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: P0C7U1; gene symbol ASAH2B.
- Organism: Homo sapiens.
- Length: 165 amino acids.
- Top disease associations (Open Targets): urate measurement, creatinine measurement and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative inactive neutral ceramidase B |
|---|---|
| UniProt accession | P0C7U1 |
| Gene | ASAH2B |
| Organism | Homo sapiens |
| Length | 165 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.35
- creatinine measurement · score 0.35
- glomerular filtration rate · score 0.34
- low density lipoprotein cholesterol measurement · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.28
- apolipoprotein B measurement · score 0.27
- triglyceride measurement · score 0.27
- total blood protein measurement · score 0.27
- total cholesterol measurement · score 0.27
- calcium measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0C7U1-F1 | alphafold | PREDICTED | 86.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0C7U1.
Amino-acid sequence (165 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASAH2B?
The strongest Open Targets associations for ASAH2B are urate measurement, creatinine measurement, glomerular filtration rate, low density lipoprotein cholesterol measurement and serum gamma-glutamyl transferase measurement.
How long is the ASAH2B protein?
The Homo sapiens ASAH2B protein (UniProt P0C7U1) is 165 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0C7U1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0C7U1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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