Spermatogenesis-associated protein 31D3 (SPATA31D3)
Homo sapiens — UniProt P0C874
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 31D3 (SPATA31D3) is a protein from Homo sapiens identified by UniProt accession P0C874, 917 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: P0C874; gene symbol SPATA31D3.
- Organism: Homo sapiens.
- Length: 917 amino acids.
- Top disease associations (Open Targets): rheumatoid arthritis, FEV/FVC ratio and visual perception measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 31D3 |
|---|---|
| UniProt accession | P0C874 |
| Gene | SPATA31D3 |
| Organism | Homo sapiens |
| Length | 917 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.19
- FEV/FVC ratio · score 0.18
- visual perception measurement · score 0.17
- schizophrenia · score 0.16
- appendicular lean mass · score 0.15
- body height · score 0.10
- autism spectrum disorder · score 0.09
- familial generalized lentiginosis · score 0.07
- acroleukopathy, symmetric · score 0.07
- familial progressive hyperpigmentation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0C874-F1 | alphafold | PREDICTED | 45.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0C874.
Amino-acid sequence (917 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA31D3?
The strongest Open Targets associations for SPATA31D3 are rheumatoid arthritis, FEV/FVC ratio, visual perception measurement, schizophrenia and appendicular lean mass.
How long is the SPATA31D3 protein?
The Homo sapiens SPATA31D3 protein (UniProt P0C874) is 917 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0C874 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0C874 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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