SLIT-ROBO Rho GTPase-activating protein 2C (SRGAP2C)
Homo sapiens — UniProt P0DJJ0
Data last refreshed: (UniProt release unknown)
Key facts
SLIT-ROBO Rho GTPase-activating protein 2C (SRGAP2C) is a protein from Homo sapiens identified by UniProt accession P0DJJ0, 459 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: P0DJJ0; gene symbol SRGAP2C.
- Organism: Homo sapiens.
- Length: 459 amino acids.
- Top disease associations (Open Targets): breast carcinoma, neutrophil count and acute lymphoblastic leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SLIT-ROBO Rho GTPase-activating protein 2C |
|---|---|
| UniProt accession | P0DJJ0 |
| Gene | SRGAP2C |
| Organism | Homo sapiens |
| Length | 459 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.35
- neutrophil count · score 0.15
- acute lymphoblastic leukemia · score 0.02
- acute myeloid leukemia · score 0.01
- gonorrhea · score 0.01
- cancer · score 0.01
- neoplasm · score 0.01
- Intellectual disability · score 0.00
- Abnormal sperm morphology · score 0.00
- azoospermia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DJJ0-F1 | alphafold | PREDICTED | 87.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DJJ0.
Amino-acid sequence (459 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRGAP2C?
The strongest Open Targets associations for SRGAP2C are breast carcinoma, neutrophil count, acute lymphoblastic leukemia, acute myeloid leukemia and gonorrhea.
How long is the SRGAP2C protein?
The Homo sapiens SRGAP2C protein (UniProt P0DJJ0) is 459 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DJJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DJJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.