Zinc finger protein 728 (ZNF728)
Homo sapiens — UniProt P0DKX0
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 728 (ZNF728) is a protein from Homo sapiens identified by UniProt accession P0DKX0, 622 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: P0DKX0; gene symbol ZNF728.
- Organism: Homo sapiens.
- Length: 622 amino acids.
- Top disease associations (Open Targets): age at menopause, menopause and Testicular Germ Cell Tumor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 728 |
|---|---|
| UniProt accession | P0DKX0 |
| Gene | ZNF728 |
| Organism | Homo sapiens |
| Length | 622 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.39
- menopause · score 0.31
- Testicular Germ Cell Tumor · score 0.31
- Down syndrome · score 0.07
- Shwachman-Diamond syndrome · score 0.03
- atypical hemolytic-uremic syndrome with C3 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with I factor anomaly · score 0.03
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly · score 0.03
- Blackfan-Diamond anemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DKX0-F1 | alphafold | PREDICTED | 69.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DKX0.
Amino-acid sequence (622 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF728?
The strongest Open Targets associations for ZNF728 are age at menopause, menopause, Testicular Germ Cell Tumor, Down syndrome and Shwachman-Diamond syndrome.
How long is the ZNF728 protein?
The Homo sapiens ZNF728 protein (UniProt P0DKX0) is 622 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DKX0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DKX0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.