Small integral membrane protein 18 (SMIM18)
Homo sapiens — UniProt P0DKX4
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 18 (SMIM18) is a protein from Homo sapiens identified by UniProt accession P0DKX4, 95 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: P0DKX4; gene symbol SMIM18.
- Organism: Homo sapiens.
- Length: 95 amino acids.
- Top disease associations (Open Targets): open-angle glaucoma, mean corpuscular hemoglobin concentration and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 18 |
|---|---|
| UniProt accession | P0DKX4 |
| Gene | SMIM18 |
| Organism | Homo sapiens |
| Length | 95 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- open-angle glaucoma · score 0.16
- mean corpuscular hemoglobin concentration · score 0.14
- creatinine measurement · score 0.13
- mean corpuscular volume · score 0.12
- mean corpuscular hemoglobin · score 0.12
- glomerular filtration rate · score 0.10
- high density lipoprotein cholesterol measurement · score 0.09
- triglyceride measurement · score 0.07
- alkaline phosphatase measurement · score 0.07
- platelet component distribution width · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DKX4-F1 | alphafold | PREDICTED | 71.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DKX4.
Amino-acid sequence (95 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM18?
The strongest Open Targets associations for SMIM18 are open-angle glaucoma, mean corpuscular hemoglobin concentration, creatinine measurement, mean corpuscular volume and mean corpuscular hemoglobin.
How long is the SMIM18 protein?
The Homo sapiens SMIM18 protein (UniProt P0DKX4) is 95 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DKX4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DKX4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.