Secreted Ly-6/uPAR domain-containing protein 2 (SLURP2)
Homo sapiens — UniProt P0DP57
Data last refreshed: (UniProt release unknown)
Key facts
Secreted Ly-6/uPAR domain-containing protein 2 (SLURP2) is a protein from Homo sapiens identified by UniProt accession P0DP57, 97 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: P0DP57; gene symbol SLURP2.
- Organism: Homo sapiens.
- Length: 97 amino acids.
- Top disease associations (Open Targets): calcium measurement, focal palmoplantar and gingival keratoderma and Ichthyosis-hypotrichosis syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Secreted Ly-6/uPAR domain-containing protein 2 |
|---|---|
| UniProt accession | P0DP57 |
| Gene | SLURP2 |
| Organism | Homo sapiens |
| Length | 97 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.07
- focal palmoplantar and gingival keratoderma · score 0.05
- Ichthyosis-hypotrichosis syndrome · score 0.05
- ichthyosis, lamellar, autosomal dominant · score 0.05
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.05
- ichthyosis hystrix of Curth-Macklin · score 0.05
- focal palmoplantar keratoderma · score 0.05
- pretibial dystrophic epidermolysis bullosa · score 0.05
- Keratoderma hereditarium mutilans with ichthyosis · score 0.05
- porokeratosis plantaris palmaris et disseminata · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DP57-F1 | alphafold | PREDICTED | 84.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DP57.
Amino-acid sequence (97 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLURP2?
The strongest Open Targets associations for SLURP2 are calcium measurement, focal palmoplantar and gingival keratoderma, Ichthyosis-hypotrichosis syndrome, ichthyosis, lamellar, autosomal dominant and hereditary palmoplantar keratoderma, Gamborg-Nielsen type.
How long is the SLURP2 protein?
The Homo sapiens SLURP2 protein (UniProt P0DP57) is 97 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DP57 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DP57 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.