Neuropeptide Y receptor type 4-2 (NPY4R2)
Homo sapiens — UniProt P0DQD5
Data last refreshed: (UniProt release unknown)
Key facts
Neuropeptide Y receptor type 4-2 (NPY4R2) is a protein from Homo sapiens identified by UniProt accession P0DQD5, 375 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: P0DQD5; gene symbol NPY4R2.
- Organism: Homo sapiens.
- Length: 375 amino acids.
- Top disease associations (Open Targets): obesity due to melanocortin 4 receptor deficiency, severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency and obesity due to leptin receptor gene deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuropeptide Y receptor type 4-2 |
|---|---|
| UniProt accession | P0DQD5 |
| Gene | NPY4R2 |
| Organism | Homo sapiens |
| Length | 375 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- obesity due to melanocortin 4 receptor deficiency · score 0.04
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.04
- obesity due to leptin receptor gene deficiency · score 0.04
- Hereditary central diabetes insipidus · score 0.03
- pancreas volume · score 0.03
- acquired central diabetes insipidus · score 0.03
- blood protein measurement · score 0.03
- pancreas fat measurement · score 0.02
- ulcerative colitis · score 0.01
- Esotropia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DQD5-F1 | alphafold | PREDICTED | 80.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DQD5.
Amino-acid sequence (375 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPY4R2?
The strongest Open Targets associations for NPY4R2 are obesity due to melanocortin 4 receptor deficiency, severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency, obesity due to leptin receptor gene deficiency, Hereditary central diabetes insipidus and pancreas volume.
How long is the NPY4R2 protein?
The Homo sapiens NPY4R2 protein (UniProt P0DQD5) is 375 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DQD5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DQD5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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