PRAME family member 15 (PRAMEF15)
Homo sapiens — UniProt P0DUQ1
Data last refreshed: (UniProt release unknown)
Key facts
PRAME family member 15 (PRAMEF15) is a protein from Homo sapiens identified by UniProt accession P0DUQ1, 478 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: P0DUQ1; gene symbol PRAMEF15.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): azoospermia, partial chromosome Y deletion and spermatogenic failures 50.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PRAME family member 15 |
|---|---|
| UniProt accession | P0DUQ1 |
| Gene | PRAMEF15 |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- spermatogenic failure 61 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DUQ1-F1 | alphafold | PREDICTED | 84.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DUQ1.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRAMEF15?
The strongest Open Targets associations for PRAMEF15 are azoospermia, partial chromosome Y deletion, spermatogenic failures 50, spermatogenic failure, X-linked, 2 and spermatogenic failure 25.
How long is the PRAMEF15 protein?
The Homo sapiens PRAMEF15 protein (UniProt P0DUQ1) is 478 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DUQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DUQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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