Speedy protein E12 (SPDYE12)
Homo sapiens — UniProt P0DUX1
Data last refreshed: (UniProt release unknown)
Key facts
Speedy protein E12 (SPDYE12) is a protein from Homo sapiens identified by UniProt accession P0DUX1, 265 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: P0DUX1; gene symbol SPDYE12.
- Organism: Homo sapiens.
- Length: 265 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, lymphocyte count and age at voice drop.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Speedy protein E12 |
|---|---|
| UniProt accession | P0DUX1 |
| Gene | SPDYE12 |
| Organism | Homo sapiens |
| Length | 265 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.35
- lymphocyte count · score 0.34
- age at voice drop · score 0.28
- estrogen-receptor negative breast cancer · score 0.28
- breast carcinoma · score 0.27
- lymphocyte percentage of leukocytes · score 0.24
- mean reticulocyte volume · score 0.21
- alcohol consumption measurement · score 0.15
- age at menarche · score 0.11
- neutrophil percentage of leukocytes · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P0DUX1-F1 | alphafold | PREDICTED | 69.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P0DUX1.
Amino-acid sequence (265 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPDYE12?
The strongest Open Targets associations for SPDYE12 are sex hormone-binding globulin measurement, lymphocyte count, age at voice drop, estrogen-receptor negative breast cancer and breast carcinoma.
How long is the SPDYE12 protein?
The Homo sapiens SPDYE12 protein (UniProt P0DUX1) is 265 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P0DUX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P0DUX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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