About Endoplasmic reticulum chaperone BiP
Endoplasmic reticulum chaperone BiP (HSPA5) is a protein
from Homo sapiens identified by UniProt accession
P11021, 654 residues long.
MolForge cross-references it against 0 known binders and
742 disease associations.
Target properties
| Protein name | Endoplasmic reticulum chaperone BiP |
|---|
| UniProt accession | P11021 |
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| Gene | HSPA5 |
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| Organism | Homo sapiens |
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| Length | 654 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (742)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- breast adenocarcinoma · score 0.26
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.12
- cancer · score 0.12
- neuroticism measurement · score 0.11
- breast cancer · score 0.11
- anxiety measurement · score 0.11
- Rheumatoid arthritis · score 0.11
- head and neck squamous cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11021-F1 | alphafold | PREDICTED | 89.99 | — |
Amino-acid sequence (654 residues)
MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL
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