Macrophage migration inhibitory factor (MIF)

About Macrophage migration inhibitory factor

Macrophage migration inhibitory factor (MIF) is a protein from Homo sapiens identified by UniProt accession P14174, 115 residues long. MolForge cross-references it against 0 known binders and 757 disease associations.

Target properties

Protein name	Macrophage migration inhibitory factor
UniProt accession	P14174
Gene	MIF
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (757)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.67
juvenile idiopathic arthritis · score 0.42
Sjogren syndrome · score 0.39
cystic fibrosis · score 0.38
systemic juvenile idiopathic arthritis · score 0.37
protein measurement · score 0.30
graft versus host disease · score 0.26
sex hormone-binding globulin measurement · score 0.23
bilirubin measurement · score 0.18
leukocyte count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14174-F1	alphafold	PREDICTED	98.59	—

Amino-acid sequence (115 residues)

MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards