Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB)
Homo sapiens — UniProt P14678
Data last refreshed: (UniProt release unknown)
Key facts
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) is a protein from Homo sapiens identified by UniProt accession P14678, 240 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: P14678; gene symbol SNRPB.
- Organism: Homo sapiens.
- Length: 240 amino acids.
- Top disease associations (Open Targets): Cerebro-costo-mandibular syndrome, cerebrocostomandibular syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small nuclear ribonucleoprotein-associated proteins B and B' |
|---|---|
| UniProt accession | P14678 |
| Gene | SNRPB |
| Organism | Homo sapiens |
| Length | 240 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- Cerebro-costo-mandibular syndrome · score 0.71
- cerebrocostomandibular syndrome · score 0.64
- neurodegenerative disease · score 0.50
- cleft palate · score 0.37
- Cleft palate · score 0.37
- Intellectual disability · score 0.26
- isolated Pierre-Robin syndrome · score 0.26
- Pierre-Robin sequence · score 0.26
- genetic disorder · score 0.17
- hepatocellular carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P14678-F1 | alphafold | PREDICTED | 69.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P14678.
Amino-acid sequence (240 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNRPB?
The strongest Open Targets associations for SNRPB are Cerebro-costo-mandibular syndrome, cerebrocostomandibular syndrome, neurodegenerative disease, cleft palate and Cleft palate.
How long is the SNRPB protein?
The Homo sapiens SNRPB protein (UniProt P14678) is 240 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P14678 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P14678 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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