Sphingomyelin phosphodiesterase (SMPD1)
Homo sapiens — UniProt P17405
Data last refreshed: (UniProt release unknown)
Key facts
Sphingomyelin phosphodiesterase (SMPD1) is a protein from Homo sapiens identified by UniProt accession P17405, 631 residues long. MolForge cross-references it against 3 known binders and 350 disease associations.
- UniProt accession: P17405; gene symbol SMPD1.
- Organism: Homo sapiens.
- Length: 631 amino acids.
- Top disease associations (Open Targets): Niemann-Pick disease type A, Niemann-Pick disease type B and Niemann-Pick disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingomyelin phosphodiesterase |
|---|---|
| UniProt accession | P17405 |
| Gene | SMPD1 |
| Organism | Homo sapiens |
| Length | 631 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (350)
Diseases linked to this target (Open Targets).
- Niemann-Pick disease type A · score 0.86
- Niemann-Pick disease type B · score 0.85
- Niemann-Pick disease · score 0.58
- neurodegenerative disease · score 0.53
- Parkinson disease · score 0.52
- lysosomal storage disease · score 0.52
- multiple sclerosis · score 0.52
- Alzheimer disease · score 0.52
- genetic disorder · score 0.47
- acid sphingomyelinase deficiency · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P17405-F1 | alphafold | PREDICTED | 88.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P17405.
Amino-acid sequence (631 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMPD1?
The strongest Open Targets associations for SMPD1 are Niemann-Pick disease type A, Niemann-Pick disease type B, Niemann-Pick disease, neurodegenerative disease and Parkinson disease.
How long is the SMPD1 protein?
The Homo sapiens SMPD1 protein (UniProt P17405) is 631 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P17405 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P17405 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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