Transcription factor PU.1 (SPI1)
Homo sapiens — UniProt P17947
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor PU.1 (SPI1) is a protein from Homo sapiens identified by UniProt accession P17947, 270 residues long. MolForge cross-references it against 0 known binders and 805 disease associations.
- UniProt accession: P17947; gene symbol SPI1.
- Organism: Homo sapiens.
- Length: 270 amino acids.
- Top disease associations (Open Targets): agammaglobulinemia 10, autosomal dominant, neurodegenerative disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor PU.1 |
|---|---|
| UniProt accession | P17947 |
| Gene | SPI1 |
| Organism | Homo sapiens |
| Length | 270 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (805)
Diseases linked to this target (Open Targets).
- agammaglobulinemia 10, autosomal dominant · score 0.67
- neurodegenerative disease · score 0.53
- Alzheimer disease · score 0.42
- autosomal agammaglobulinemia · score 0.37
- multiple sclerosis · score 0.37
- Parkinson disease · score 0.37
- lysosomal storage disease · score 0.37
- apolipoprotein A 1 measurement · score 0.29
- total blood protein measurement · score 0.27
- serum albumin measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P17947-F1 | alphafold | PREDICTED | 65.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P17947.
Amino-acid sequence (270 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPI1?
The strongest Open Targets associations for SPI1 are agammaglobulinemia 10, autosomal dominant, neurodegenerative disease, Alzheimer disease, autosomal agammaglobulinemia and multiple sclerosis.
How long is the SPI1 protein?
The Homo sapiens SPI1 protein (UniProt P17947) is 270 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P17947 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P17947 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.