Sodium/hydrogen exchanger 1 (SLC9A1)
Homo sapiens — UniProt P19634
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/hydrogen exchanger 1 (SLC9A1) is a protein from Homo sapiens identified by UniProt accession P19634, 815 residues long. MolForge cross-references it against 1 known binders and 463 disease associations.
- UniProt accession: P19634; gene symbol SLC9A1.
- Organism: Homo sapiens.
- Length: 815 amino acids.
- Top disease associations (Open Targets): Lichtenstein-Knorr syndrome, genetic disorder and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/hydrogen exchanger 1 |
|---|---|
| UniProt accession | P19634 |
| Gene | SLC9A1 |
| Organism | Homo sapiens |
| Length | 815 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (463)
Diseases linked to this target (Open Targets).
- Lichtenstein-Knorr syndrome · score 0.65
- genetic disorder · score 0.30
- body height · score 0.25
- cutaneous melanoma · score 0.15
- lung adenocarcinoma · score 0.12
- neoplasm · score 0.11
- acute myeloid leukemia · score 0.10
- azoospermia · score 0.09
- Generalized epilepsy with febrile seizures-plus · score 0.08
- generalised epilepsy · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P19634-F1 | alphafold | PREDICTED | 67.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P19634.
Amino-acid sequence (815 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC9A1?
The strongest Open Targets associations for SLC9A1 are Lichtenstein-Knorr syndrome, genetic disorder, body height, cutaneous melanoma and lung adenocarcinoma.
How long is the SLC9A1 protein?
The Homo sapiens SLC9A1 protein (UniProt P19634) is 815 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P19634 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P19634 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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