Serine protease inhibitor Kazal-type 2 (SPINK2)
Homo sapiens — UniProt P20155
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 2 (SPINK2) is a protein from Homo sapiens identified by UniProt accession P20155, 84 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.
- UniProt accession: P20155; gene symbol SPINK2.
- Organism: Homo sapiens.
- Length: 84 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 29, blood protein measurement and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 2 |
|---|---|
| UniProt accession | P20155 |
| Gene | SPINK2 |
| Organism | Homo sapiens |
| Length | 84 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (168)
Diseases linked to this target (Open Targets).
- spermatogenic failure 29 · score 0.47
- blood protein measurement · score 0.44
- azoospermia · score 0.40
- reticulocyte count · score 0.36
- reticulocyte measurement · score 0.31
- viral load · score 0.27
- mean corpuscular volume · score 0.21
- cortical surface area measurement · score 0.21
- Immature Reticulocyte Fraction Measurement · score 0.16
- smoking initiation · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P20155-F1 | alphafold | PREDICTED | 85.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P20155.
Amino-acid sequence (84 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK2?
The strongest Open Targets associations for SPINK2 are spermatogenic failure 29, blood protein measurement, azoospermia, reticulocyte count and reticulocyte measurement.
How long is the SPINK2 protein?
The Homo sapiens SPINK2 protein (UniProt P20155) is 84 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P20155 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P20155 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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