About Carbonic anhydrase 4
Carbonic anhydrase 4 (CA4) is a protein
from Homo sapiens identified by UniProt accession
P22748, 312 residues long.
MolForge cross-references it against 0 known binders and
277 disease associations.
Target properties
| Protein name | Carbonic anhydrase 4 |
|---|
| UniProt accession | P22748 |
|---|
| Gene | CA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 312 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (277)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.61
- glaucoma · score 0.60
- altitude sickness · score 0.60
- Seizure · score 0.60
- migraine disorder · score 0.60
- angle-closure glaucoma · score 0.59
- edema · score 0.59
- obesity · score 0.57
- chronic obstructive pulmonary disease · score 0.57
- heart failure · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22748-F1 | alphafold | PREDICTED | 89.15 | — |
Amino-acid sequence (312 residues)
MRMLLALLAL SAARPSASAE SHWCYEVQAE SSNYPCLVPV KWGGNCQKDR QSPINIVTTK AKVDKKLGRF FFSGYDKKQT WTVQNNGHSV MMLLENKASI SGGGLPAPYQ AKQLHLHWSD LPYKGSEHSL DGEHFAMEMH IVHEKEKGTS RNVKEAQDPE DEIAVLAFLV EAGTQVNEGF QPLVEALSNI PKPEMSTTMA ESSLLDLLPK EEKLRHYFRY LGSLTTPTCD EKVVWTVFRE PIQLHREQIL AFSQKLYYDK EQTVSMKDNV RPLQQLGQRT VIKSGAPGRP LPWALPALLG PMLACLLAGF LR
Explore Carbonic anhydrase 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets