About Liver carboxylesterase 1
Liver carboxylesterase 1 (CES1) is a protein
from Homo sapiens identified by UniProt accession
P23141, 567 residues long.
MolForge cross-references it against 0 known binders and
193 disease associations.
Target properties
| Protein name | Liver carboxylesterase 1 |
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| UniProt accession | P23141 |
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| Gene | CES1 |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (193)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.33
- alkaline phosphatase measurement · score 0.30
- low density lipoprotein cholesterol measurement · score 0.21
- neurodegenerative disease · score 0.21
- glioblastoma multiforme · score 0.16
- hepatocellular carcinoma · score 0.08
- atherosclerosis · score 0.06
- Blackfan-Diamond anemia · score 0.06
- glycogen storage disease VI · score 0.06
- LIPE-related familial partial lipodystrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23141-F1 | alphafold | PREDICTED | 93.30 | — |
Amino-acid sequence (567 residues)
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL FAKKAVEKPP QTEHIEL
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