Nuclear autoantigen Sp-100 (SP100)
Homo sapiens — UniProt P23497
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear autoantigen Sp-100 (SP100) is a protein from Homo sapiens identified by UniProt accession P23497, 879 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: P23497; gene symbol SP100.
- Organism: Homo sapiens.
- Length: 879 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, sex hormone-binding globulin measurement and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear autoantigen Sp-100 |
|---|---|
| UniProt accession | P23497 |
| Gene | SP100 |
| Organism | Homo sapiens |
| Length | 879 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- sex hormone-binding globulin measurement · score 0.41
- monocyte count · score 0.37
- gut microbiome measurement · score 0.24
- ovarian cancer · score 0.23
- endometrial cancer · score 0.23
- low grade glioma · score 0.23
- systolic blood pressure · score 0.23
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P23497-F1 | alphafold | PREDICTED | 56.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P23497.
Amino-acid sequence (879 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP100?
The strongest Open Targets associations for SP100 are neurodegenerative disease, sex hormone-binding globulin measurement, monocyte count, gut microbiome measurement and ovarian cancer.
How long is the SP100 protein?
The Homo sapiens SP100 protein (UniProt P23497) is 879 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P23497 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P23497 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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