Endothelin receptor type B (EDNRB)

About Endothelin receptor type B

Endothelin receptor type B (EDNRB) is a protein from Homo sapiens identified by UniProt accession P24530, 442 residues long. MolForge cross-references it against 0 known binders and 616 disease associations.

Target properties

Protein name	Endothelin receptor type B
UniProt accession	P24530
Gene	EDNRB
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (9)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (616)

Diseases linked to this target (Open Targets).

Waardenburg syndrome type 4A · score 0.75
ABCD syndrome · score 0.71
pulmonary arterial hypertension · score 0.61
Hirschsprung disease · score 0.58
pulmonary hypertension · score 0.58
hypertension · score 0.57
systemic scleroderma · score 0.54
lean body mass · score 0.51
type 2 diabetes mellitus · score 0.51
Waardenburg-Shah syndrome · score 0.51

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24530-F1	alphafold	PREDICTED	75.02	—

Amino-acid sequence (442 residues)

MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC QGPIEIKETF KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH IVIDIPINVY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DIITMDYKGS YLRICLLHPV QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY NQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards