Sitaxentan

CARDIOVASCULAR SYSTEM

Key facts

Sitaxentan is a drug catalogued in DrugCentral. It was first approved by the EMA in 2006. DrugCentral lists 3 molecular targets, including EDNRA, Ednra and EDNRB. Recorded indications include Pulmonary arterial hypertension.

• Molecular targets: EDNRA, Ednra and EDNRB (3 listed in DrugCentral).
• Indications: Pulmonary arterial hypertension.
• ATC code: C02KX03 (Antihypertensives for pulmonary arterial hypertension).
• Molecular formula: C18H15ClN2O6S2; molecular weight 454.90 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Pulmonary arterial hypertension

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Endothelin-1 receptor	EDNRA	antagonist	Ki 9.37
Endothelin-1 receptor	Ednra	antagonist	Ki 9.37
Endothelin B receptor	EDNRB	antagonist	IC50 5.01

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2006-08-10	EMA	—	Pfizer Ltd

ATC classification

ATC code	Therapeutic hierarchy
C02KX03	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › OTHER ANTIHYPERTENSIVES › Antihypertensives for pulmonary arterial hypertension

Chemical structure

• Molecular formula: C₁₈H₁₅ClN₂O₆S₂
• Molecular weight: 454.90 g/mol
• CAS number: 210421-74-2
• InChIKey: PHWXUGHIIBDVKD-UHFFFAOYSA-N
• PubChem CID: 216235

CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC2=CC3=C(OCO3)C=C2C)=C1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Sitaxentan used for?

DrugCentral lists the following indications for Sitaxentan: Pulmonary arterial hypertension.

How does Sitaxentan work?

Its molecular targets in DrugCentral include EDNRA (antagonist), Ednra (antagonist) and EDNRB (antagonist).

When was Sitaxentan first approved?

Sitaxentan was first approved by the EMA in 2006.

What is the chemical formula of Sitaxentan?

Sitaxentan has the molecular formula C18H15ClN2O6S2 and a molecular weight of 454.90 g/mol.

Sources

• DrugCentral drug card 3548 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2105740 — compound record and bioactivity
• PubChem CID 216235 — chemical identifiers
• DrugBank DB06268 — drug record
• FDA UNII J9QH779MEM — substance identity
• UniProt P25101 (EDNRA) — target protein
• UniProt P24530 (EDNRB) — target protein

How this page is built: methodology · editorial policy & corrections.