About Endothelin-1 receptor
Endothelin-1 receptor (EDNRA) is a protein
from Homo sapiens identified by UniProt accession
P25101, 427 residues long.
MolForge cross-references it against 0 known binders and
675 disease associations.
Target properties
| Protein name | Endothelin-1 receptor |
|---|
| UniProt accession | P25101 |
|---|
| Gene | EDNRA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 427 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (675)
Diseases linked to this target (Open Targets).
- mandibulofacial dysostosis with alopecia · score 0.76
- hypertension · score 0.65
- pulmonary arterial hypertension · score 0.61
- pulmonary hypertension · score 0.58
- systemic scleroderma · score 0.55
- coronary artery disease · score 0.54
- congenital heart disease · score 0.51
- angina pectoris · score 0.50
- type 2 diabetes mellitus · score 0.50
- brain aneurysm · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25101-F1 | alphafold | PREDICTED | 74.38 | — |
Amino-acid sequence (427 residues)
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS SHKDSMN
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