Atrasentan

Endothelin Receptor Antagonist

Key facts

Atrasentan is an onp drug in the Endothelin Receptor Antagonist class catalogued in DrugCentral. It was first approved by the FDA in 2025. Its mechanism of action is classified as Endothelin Receptor Antagonists. DrugCentral lists 2 molecular targets, including EDNRA and EDNRB. Recorded indications include Primary immunoglobulin A nephropathy.

• Approval status: onp (first approved 2025 by the FDA).
• Drug class: Endothelin Receptor Antagonist.
• Mechanism of action: Endothelin Receptor Antagonists.
• Molecular targets: EDNRA and EDNRB (2 listed in DrugCentral).
• Indications: Primary immunoglobulin A nephropathy.
• Molecular formula: C29H38N2O6; molecular weight 510.63 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Primary immunoglobulin A nephropathy

Mechanism & targets

• Mechanism of action (MoA): Endothelin Receptor Antagonists
• Established pharmacologic class: Endothelin Receptor Antagonist

Molecular targets (2)

Target	Gene	Action	Activity
Endothelin-1 receptor	EDNRA	antagonist	Ki 10.47
Endothelin B receptor	EDNRB	antagonist	Ki 10.47

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-04-02	FDA	—	Novartis	Yes

Chemical structure

• Molecular formula: C₂₉H₃₈N₂O₆
• Molecular weight: 510.63 g/mol
• CAS number: —
• InChIKey: MOTJMGVDPWRKOC-QPVYNBJUSA-N
• PubChem CID: 159594

CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1C2=CC=C(C=C2)OC)C(=O)O)C3=CC4=C(C=C3)OCO4

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Atrasentan used for?

DrugCentral lists the following indications for Atrasentan: Primary immunoglobulin A nephropathy.

How does Atrasentan work?

Atrasentan is classified as Endothelin Receptor Antagonists; its molecular targets in DrugCentral include EDNRA (antagonist) and EDNRB (antagonist).

When was Atrasentan first approved?

Atrasentan was first approved by the FDA in 2025.

What drug class does Atrasentan belong to?

Atrasentan is in the Endothelin Receptor Antagonist class.

What is the chemical formula of Atrasentan?

Atrasentan has the molecular formula C29H38N2O6 and a molecular weight of 510.63 g/mol.

Sources

• DrugCentral drug card 5767 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2106068 — compound record and bioactivity
• PubChem CID 159594 — chemical identifiers
• DrugBank DB06199 — drug record
• FDA UNII V6D7VK2215 — substance identity
• DailyMed: FDA labels for Atrasentan — current prescribing information (label search)
• UniProt P25101 (EDNRA) — target protein
• UniProt P24530 (EDNRB) — target protein

How this page is built: methodology · editorial policy & corrections.