SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1)
Homo sapiens — UniProt P28370
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) is a protein from Homo sapiens identified by UniProt accession P28370, 1042 residues long. MolForge cross-references it against 0 known binders and 254 disease associations.
- UniProt accession: P28370; gene symbol SMARCA1.
- Organism: Homo sapiens.
- Length: 1042 amino acids.
- Top disease associations (Open Targets): Abnormal brain morphology, prostate adenocarcinoma and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 |
|---|---|
| UniProt accession | P28370 |
| Gene | SMARCA1 |
| Organism | Homo sapiens |
| Length | 1042 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (254)
Diseases linked to this target (Open Targets).
- Abnormal brain morphology · score 0.27
- prostate adenocarcinoma · score 0.26
- cancer · score 0.21
- response to darapladib · score 0.15
- Diarrhea · score 0.15
- X-linked intellectual disability · score 0.12
- genetic disorder · score 0.12
- neoplasm · score 0.09
- melanoma · score 0.07
- Mobius syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P28370-F1 | alphafold | PREDICTED | 74.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P28370.
Amino-acid sequence (1042 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCA1?
The strongest Open Targets associations for SMARCA1 are Abnormal brain morphology, prostate adenocarcinoma, cancer, response to darapladib and Diarrhea.
How long is the SMARCA1 protein?
The Homo sapiens SMARCA1 protein (UniProt P28370) is 1042 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P28370 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P28370 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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