About 11-beta-hydroxysteroid dehydrogenase 1
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) is a protein
from Homo sapiens identified by UniProt accession
P28845, 292 residues long.
MolForge cross-references it against 0 known binders and
253 disease associations.
Target properties
| Protein name | 11-beta-hydroxysteroid dehydrogenase 1 |
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| UniProt accession | P28845 |
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| Gene | HSD11B1 |
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| Organism | Homo sapiens |
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| Length | 292 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (253)
Diseases linked to this target (Open Targets).
- Hyperandrogenism due to cortisone reductase deficiency · score 0.55
- Peptic ulcer · score 0.50
- gastroesophageal reflux disease · score 0.50
- mean reticulocyte volume · score 0.23
- erythrocyte count · score 0.20
- squamous cell lung carcinoma · score 0.18
- mean corpuscular hemoglobin · score 0.16
- type 2 diabetes mellitus · score 0.13
- exstrophy-epispadias complex · score 0.12
- cutaneous melanoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28845-F1 | alphafold | PREDICTED | 94.72 | — |
Amino-acid sequence (292 residues)
MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK
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