High affinity cationic amino acid transporter 1 (SLC7A1)
Homo sapiens — UniProt P30825
Data last refreshed: (UniProt release unknown)
Key facts
High affinity cationic amino acid transporter 1 (SLC7A1) is a protein from Homo sapiens identified by UniProt accession P30825, 629 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.
- UniProt accession: P30825; gene symbol SLC7A1.
- Organism: Homo sapiens.
- Length: 629 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): hypertension, systolic blood pressure and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | High affinity cationic amino acid transporter 1 |
|---|---|
| UniProt accession | P30825 |
| Gene | SLC7A1 |
| Organism | Homo sapiens |
| Length | 629 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (264)
Diseases linked to this target (Open Targets).
- hypertension · score 0.50
- systolic blood pressure · score 0.46
- lean body mass · score 0.43
- diastolic blood pressure · score 0.42
- Agents acting on the renin-angiotensin system use measurement · score 0.42
- Diuretic use measurement · score 0.41
- body height · score 0.40
- appendicular lean mass · score 0.39
- PHF-tau measurement · score 0.37
- fat body mass · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P30825-F1 | alphafold | PREDICTED | 82.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P30825.
Amino-acid sequence (629 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC7A1?
The strongest Open Targets associations for SLC7A1 are hypertension, systolic blood pressure, lean body mass, diastolic blood pressure and Agents acting on the renin-angiotensin system use measurement.
How long is the SLC7A1 protein?
The Homo sapiens SLC7A1 protein (UniProt P30825) is 629 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P30825 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P30825 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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