About Gastrin/cholecystokinin type B receptor
Gastrin/cholecystokinin type B receptor (CCKBR) is a protein
from Homo sapiens identified by UniProt accession
P32239, 447 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | Gastrin/cholecystokinin type B receptor |
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| UniProt accession | P32239 |
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| Gene | CCKBR |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (207)
Diseases linked to this target (Open Targets).
- gastroesophageal reflux disease · score 0.41
- Peptic ulcer · score 0.37
- ovarian cancer · score 0.26
- breast adenocarcinoma · score 0.25
- diastolic blood pressure · score 0.21
- pancreatic adenocarcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.16
- duodenal ulcer · score 0.16
- mathematical ability · score 0.16
- peptic ulcer disease · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32239-F1 | alphafold | PREDICTED | 75.73 | — |
Amino-acid sequence (447 residues)
MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL PDEDPPTPSI ASLSRLSYTT ISTLGPG
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