Melanocortin receptor 4 (MC4R)

About Melanocortin receptor 4

Melanocortin receptor 4 (MC4R) is a protein from Homo sapiens identified by UniProt accession P32245, 332 residues long. MolForge cross-references it against 0 known binders and 430 disease associations.

Target properties

Protein name	Melanocortin receptor 4
UniProt accession	P32245
Gene	MC4R
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (430)

Diseases linked to this target (Open Targets).

obesity · score 0.80
lean body mass · score 0.73
body mass index · score 0.72
fat body mass · score 0.72
body fat percentage · score 0.72
body weight · score 0.71
hip circumference · score 0.70
waist circumference · score 0.69
base metabolic rate measurement · score 0.68
obesity due to melanocortin 4 receptor deficiency · score 0.67

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32245-F1	alphafold	PREDICTED	80.14	—

Amino-acid sequence (332 residues)

MVNSTHRGMH TSLHLWNRSS YRLHSNASES LGKGYSDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVKRVGIII SCIWAACTVS GILFIIYSDS SAVIICLITM FFTMLALMAS LYVHMFLMAR LHIKRIAVLP GTGAIRQGAN MKGAITLTIL IGVFVVCWAP FFLHLIFYIS CPQNPYCVCF MSHFNLYLIL IMCNSIIDPL IYALRSQELR KTFKEIICCY PLGGLCDLSS RY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards