Colistin

ALIMENTARY TRACT AND METABOLISM

Key facts

Colistin is a drug catalogued in DrugCentral. It was first approved by the FDA in 1962. DrugCentral lists 6 molecular targets, including MC3R, MC5R and MC4R. Recorded indications include Enterobacter Infection, Infection due to Escherichia coli, Klebsiella Infections and Mastoidectomy Cavity Infections.

• Molecular targets: MC3R, MC5R, MC4R and FYN (6 listed in DrugCentral).
• Indications: Enterobacter Infection, Infection due to Escherichia coli, Klebsiella Infections, Mastoidectomy Cavity Infections and Otitis externa and others.
• ATC code: A07AA10 (Antibiotics).
• Molecular formula: C105H198N32O26; molecular weight 2324.94 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Enterobacter Infection
• Infection due to Escherichia coli
• Klebsiella Infections
• Mastoidectomy Cavity Infections
• Otitis externa
• Pseudomonas Aeruginosa Infections

Off-label uses (2)

• Chronic purulent otitis media
• Pseudomonas Respiratory Tract Infection in Cystic Fibrosis

Contraindications (11)

• Bullous myringitis
• Fungal ear infection
• Herpes simplex
• Herpes zoster auricularis
• Kidney disease
• Myasthenia gravis
• Neuromuscular block, function
• Perforation of tympanic membrane
• Pseudomembranous enterocolitis
• Tuberculosis of ear
• Viral ear infection

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Melanocortin receptor 3	MC3R	unknown	Ki 6.78
Melanocortin receptor 5	MC5R	unknown	Ki 6.60
Melanocortin receptor 4	MC4R	unknown	Ki 6.09
Tyrosine-protein kinase Fyn	FYN	unknown	IC50 6.02
Epidermal growth factor receptor	EGFR	unknown	IC50 5.82
Receptor tyrosine-protein kinase erbB-2	ERBB2	unknown	IC50 5.65

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1962-05-17	FDA	—	PAR STERILE PRODUCTS

ATC classification

ATC code	Therapeutic hierarchy
A07AA10	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
J01XB01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Polymyxins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug resistance	515.3
Pathogen resistance	382.5
Choroiditis	316.3
Septic shock	303.4
Multiple organ dysfunction syndrome	289.5
Drug ineffective	267.4
Infective pulmonary exacerbation of cystic fibrosis	245.1
Endophthalmitis	221.2
Pseudomonas infection	180.0
Intraocular pressure increased	174.7
Geotrichum infection	172.3
Klebsiella infection	144.3

Chemical structure

• Molecular formula: C₁₀₅H₁₉₈N₃₂O₂₆
• Molecular weight: 2324.94 g/mol
• CAS number: 1066-17-7
• InChIKey: —
• PubChem CID: 5311054

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Colistin used for?

DrugCentral lists the following indications for Colistin: Enterobacter Infection, Infection due to Escherichia coli, Klebsiella Infections, Mastoidectomy Cavity Infections, Otitis externa and Pseudomonas Aeruginosa Infections.

How does Colistin work?

Its molecular targets in DrugCentral include MC3R, MC5R, MC4R and FYN.

When was Colistin first approved?

Colistin was first approved by the FDA in 1962.

What is the chemical formula of Colistin?

Colistin has the molecular formula C105H198N32O26 and a molecular weight of 2324.94 g/mol.

Sources

• DrugCentral drug card 4425 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201441 — compound record and bioactivity
• PubChem CID 5311054 — chemical identifiers
• DrugBank DB00803 — drug record
• FDA UNII Z67X93HJG1 — substance identity
• DailyMed: FDA labels for Colistin — current prescribing information (label search)
• UniProt P41968 (MC3R) — target protein
• UniProt P33032 (MC5R) — target protein
• UniProt P32245 (MC4R) — target protein
• UniProt P06241 (FYN) — target protein
• UniProt P00533 (EGFR) — target protein
• UniProt P04626 (ERBB2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.