Streptomycin

Aminoglycoside Antibacterial — ALIMENTARY TRACT AND METABOLISM

Key facts

Streptomycin is an ofp drug in the Aminoglycoside Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1946. DrugCentral lists 1 molecular target, including rpsL. Recorded indications include Acute tuberculosis, Aerobic Gram-Negative Bacteremia, Bacterial urinary infection and Brucellosis.

• Approval status: ofp (first approved 1946 by the FDA).
• Drug class: Aminoglycoside Antibacterial; Antimycobacterial.
• Molecular targets: rpsL (1 listed in DrugCentral).
• Indications: Acute tuberculosis, Aerobic Gram-Negative Bacteremia, Bacterial urinary infection, Brucellosis and Chancroid and others.
• ATC code: A07AA04 (Antibiotics).
• Molecular formula: C21H39N7O12; molecular weight 581.58 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (19)

• Acute tuberculosis
• Aerobic Gram-Negative Bacteremia
• Bacterial urinary infection
• Brucellosis
• Chancroid
• Enterococcus Urinary Tract Infection
• Escherichia coli urinary tract infection
• Granuloma inguinale
• H. Influenzae Meningitis
• Haemophilus Endocarditis
• Haemophilus influenzae pneumonia
• Klebsiella cystitis
• Plague
• Proteus urinary tract infection
• Pulmonary tuberculosis
• Synergy for Enterococcal Endocarditis
• Synergy for Enterococcal Infections
• Synergy for Streptococcal Endocarditis
• Tularemia

Off-label uses (1)

• Pulmonary Mycobacterium avium complex infection

Contraindications (11)

• Dehydration
• Disorder of the 8th Cranial Nerve
• Hypocalcemia
• Infant Botulism
• Inner Ear Disturbance
• Kidney disease
• Myasthenia gravis
• Parkinsonism
• Pregnancy, function
• Tinnitus
• Vertigo

Mechanism & targets

• Established pharmacologic class: Aminoglycoside Antibacterial; Antimycobacterial

Molecular targets (1)

Target	Gene	Action	Activity
30S ribosomal protein S12	rpsL	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1946-02-18	FDA	—	PFIZER

ATC classification

ATC code	Therapeutic hierarchy
A07AA04	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
A07AA54	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
J01GA01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › AMINOGLYCOSIDE ANTIBACTERIALS › Streptomycins
J04AM01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF TUBERCULOSIS › Combinations of drugs for treatment of tuberculosis

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: MT-RNR1 · Actionable PGx
• HCSC label

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug resistance	212.2
Paradoxical drug reaction	177.6
Immune reconstitution inflammatory syndrome associated tuberculosis	173.6
Tuberculoma of central nervous system	111.4
Pathogen resistance	96.2
Drug reaction with eosinophilia and systemic symptoms	79.9
Urinary tract inflammation	79.8
Immune reconstitution inflammatory syndrome	76.5
Hepatitis cholestatic	75.7
Vaginal flatulence	74.9
Drug-induced liver injury	70.7
Female genital tract fistula	67.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Streptomycin is on its molecule page.

• Molecular formula: C₂₁H₃₉N₇O₁₂
• Molecular weight: 581.58 g/mol
• CAS number: —
• InChIKey: UCSJYZPVAKXKNQ-HZYVHMACSA-N
• PubChem CID: 19649

CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)C=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Streptomycin used for?

DrugCentral lists the following indications for Streptomycin: Acute tuberculosis, Aerobic Gram-Negative Bacteremia, Bacterial urinary infection, Brucellosis, Chancroid, Enterococcus Urinary Tract Infection, Escherichia coli urinary tract infection and Granuloma inguinale and others.

How does Streptomycin work?

Its molecular targets in DrugCentral include rpsL.

When was Streptomycin first approved?

Streptomycin was first approved by the FDA in 1946.

What drug class does Streptomycin belong to?

Streptomycin is in the Aminoglycoside Antibacterial class.

What is the chemical formula of Streptomycin?

Streptomycin has the molecular formula C21H39N7O12 and a molecular weight of 581.58 g/mol.

Sources

• DrugCentral drug card 2481 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3184791 — compound record and bioactivity
• PubChem CID 19649 — chemical identifiers
• DrugBank DB01082 — drug record
• FDA UNII Y45QSO73OB — substance identity
• DailyMed: FDA labels for Streptomycin — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.