About Melanocortin receptor 5
Melanocortin receptor 5 (MC5R) is a protein
from Homo sapiens identified by UniProt accession
P33032, 325 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Melanocortin receptor 5 |
|---|
| UniProt accession | P33032 |
|---|
| Gene | MC5R |
|---|
| Organism | Homo sapiens |
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| Length | 325 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (94)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.25
- ovarian cancer · score 0.25
- DNA methylation · score 0.24
- hip bone mineral density · score 0.18
- fat body mass · score 0.18
- lean mass-adjusted fat body mass · score 0.18
- femoral neck bone mineral density · score 0.18
- breast adenocarcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.16
- cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33032-F1 | alphafold | PREDICTED | 82.60 | — |
Amino-acid sequence (325 residues)
MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS LLENILVIGA IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF VRHIDNVFDS MICISVVASM CSLLAIAVDR YVTIFYALRY HHIMTARRSG AIIAGIWAFC TGCGIVFILY SESTYVILCL ISMFFAMLFL LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV TMLLGVFTVC WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ EMRKTFKEII CCRGFRIACS FPRRD
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