Melanocortin receptor 3 (MC3R)

About Melanocortin receptor 3

Melanocortin receptor 3 (MC3R) is a protein from Homo sapiens identified by UniProt accession P41968, 323 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Melanocortin receptor 3
UniProt accession	P41968
Gene	MC3R
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (11)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (132)

Diseases linked to this target (Open Targets).

age at menarche · score 0.41
body height · score 0.41
lean body mass · score 0.33
age at first facial hair · score 0.32
appendicular lean mass · score 0.30
age at voice drop · score 0.26
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.25
puberty onset measurement · score 0.24
fat body mass · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41968-F1	alphafold	PREDICTED	83.87	—

Amino-acid sequence (323 residues)

MNASCCLPSV QPTLPNGSEH LQAPFFSNQS SSAFCEQVFI KPEVFLSLGI VSLLENILVI LAVVRNGNLH SPMYFFLCSL AVADMLVSVS NALETIMIAI VHSDYLTFED QFIQHMDNIF DSMICISLVA SICNLLAIAV DRYVTIFYAL RYHSIMTVRK ALTLIVAIWV CCGVCGVVFI VYSESKMVIV CLITMFFAMM LLMGTLYVHM FLFARLHVKR IAALPPADGV APQQHSCMKG AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA FRSLELRNTF REILCGCNGM NLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards