Polymyxin B

Polymyxin-class Antibacterial — ALIMENTARY TRACT AND METABOLISM

Key facts

Polymyxin B is a drug in the Polymyxin-class Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1957. Recorded indications include Bacterial conjunctivitis, Bacterial keratitis, Bacterial septicemia and Blepharoconjunctivitis.

• Drug class: Polymyxin-class Antibacterial.
• Indications: Bacterial conjunctivitis, Bacterial keratitis, Bacterial septicemia, Blepharoconjunctivitis and Corneal abrasion and others.
• ATC code: A07AA05 (Antibiotics).
• Molecular formula: C111H194N32O26; molecular weight 2392.97 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (15)

• Bacterial conjunctivitis
• Bacterial keratitis
• Bacterial septicemia
• Blepharoconjunctivitis
• Corneal abrasion
• H. Influenzae Meningitis
• Infective blepharitis
• Keratitis
• Mastoidectomy Cavity Infections
• Minor Bacterial Skin Infections
• Minor Skin Wound Pain
• Otitis externa
• Superficial Ocular Infection
• Urinary tract infectious disease
• Uveitis

Off-label uses (4)

• Chronic purulent otitis media
• Corneal ulcer
• Dacryocystitis
• Meibomianitis

Contraindications (36)

• Adrenal cortical hypofunction
• Atrophoderma
• Bacterial infection of eye
• Bullous myringitis
• Dehydration
• Diabetes mellitus
• Eye infection
• Fungal ear infection
• Fungal infection of eye
• Hearing disorder
• Herpes simplex
• Herpes simplex dendritic keratitis
• Herpes simplex keratitis
• Herpes zoster auricularis
• Injury of eye region
• Kidney disease
• Krukenberg spindle
• Myasthenia gravis
• Neuromuscular block, function
• Ocular hypertension
• Oliguria
• Open wound
• Open-angle glaucoma
• Perforation of tympanic membrane
• Peripheral vascular disease
• Pregnancy, function
• Procedure on urinary system
• Rupture of bladder
• Severe myopia
• Telangiectasia disorder
• + 6 more

Mechanism & targets

• Established pharmacologic class: Polymyxin-class Antibacterial

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1957-03-26	FDA	—	MONARCH PHARMS

ATC classification

ATC code	Therapeutic hierarchy
A07AA05	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
J01XB02	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Polymyxins
S01AA18	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
S02AA11	SENSORY ORGANS › OTOLOGICALS › ANTIINFECTIVES › Antiinfectives
S03AA03	SENSORY ORGANS › OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS › ANTIINFECTIVES › Antiinfectives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Local anaesthetic systemic toxicity	1846.9
Anaphylactic shock	527.6
Anaphylactic reaction	520.5
Cardiac arrest	485.8
Methaemoglobinaemia	451.3
Toxic anterior segment syndrome	356.3
Maternal exposure during delivery	332.8
Pemphigus	295.4
Hypotension	293.4
Hand deformity	284.8
Systemic lupus erythematosus	283.3
Nasal oedema	280.8

Chemical structure

• Molecular formula: C₁₁₁H₁₉₄N₃₂O₂₆
• Molecular weight: 2392.97 g/mol
• CAS number: 1405-20-5
• InChIKey: —
• PubChem CID: 5702105

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Polymyxin B used for?

DrugCentral lists the following indications for Polymyxin B: Bacterial conjunctivitis, Bacterial keratitis, Bacterial septicemia, Blepharoconjunctivitis, Corneal abrasion, H. Influenzae Meningitis, Infective blepharitis and Keratitis and others.

When was Polymyxin B first approved?

Polymyxin B was first approved by the FDA in 1957.

What drug class does Polymyxin B belong to?

Polymyxin B is in the Polymyxin-class Antibacterial class.

What is the chemical formula of Polymyxin B?

Polymyxin B has the molecular formula C111H194N32O26 and a molecular weight of 2392.97 g/mol.

Sources

• DrugCentral drug card 4246 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL5314354 — compound record and bioactivity
• PubChem CID 5702105 — chemical identifiers
• DrugBank DB00781 — drug record
• FDA UNII J2VZ07J96K — substance identity
• DailyMed: FDA labels for Polymyxin B — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.