Sodium/calcium exchanger 1 (SLC8A1)
Homo sapiens — UniProt P32418
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/calcium exchanger 1 (SLC8A1) is a protein from Homo sapiens identified by UniProt accession P32418, 973 residues long. MolForge cross-references it against 1 known binders and 354 disease associations.
- UniProt accession: P32418; gene symbol SLC8A1.
- Organism: Homo sapiens.
- Length: 973 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, PR interval and QT interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/calcium exchanger 1 |
|---|---|
| UniProt accession | P32418 |
| Gene | SLC8A1 |
| Organism | Homo sapiens |
| Length | 973 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (354)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.47
- PR interval · score 0.45
- QT interval · score 0.45
- electrocardiography · score 0.45
- protein measurement · score 0.45
- glomerular filtration rate · score 0.42
- diastolic blood pressure · score 0.41
- systolic blood pressure · score 0.41
- bone density · score 0.40
- TPE interval measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P32418-F1 | alphafold | PREDICTED | 74.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P32418.
Amino-acid sequence (973 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC8A1?
The strongest Open Targets associations for SLC8A1 are heel bone mineral density, PR interval, QT interval, electrocardiography and protein measurement.
How long is the SLC8A1 protein?
The Homo sapiens SLC8A1 protein (UniProt P32418) is 973 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P32418 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P32418 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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