Transcription factor SOX-18 (SOX18)
Homo sapiens — UniProt P35713
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-18 (SOX18) is a protein from Homo sapiens identified by UniProt accession P35713, 384 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.
- UniProt accession: P35713; gene symbol SOX18.
- Organism: Homo sapiens.
- Length: 384 amino acids.
- Top disease associations (Open Targets): Hypotrichosis - lymphedema - telangiectasia, neurodegenerative disease and Glomerulonephritis - sparse hair - telangiectasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-18 |
|---|---|
| UniProt accession | P35713 |
| Gene | SOX18 |
| Organism | Homo sapiens |
| Length | 384 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (239)
Diseases linked to this target (Open Targets).
- Hypotrichosis - lymphedema - telangiectasia · score 0.77
- neurodegenerative disease · score 0.56
- Glomerulonephritis - sparse hair - telangiectasis · score 0.37
- genetic disorder · score 0.19
- Varicose veins · score 0.12
- bladder exstrophy · score 0.12
- hepatocellular carcinoma · score 0.10
- lymphatic system disease · score 0.10
- vein disorder · score 0.10
- hypotrichosis simplex · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P35713-F1 | alphafold | PREDICTED | 62.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P35713.
Amino-acid sequence (384 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX18?
The strongest Open Targets associations for SOX18 are Hypotrichosis - lymphedema - telangiectasia, neurodegenerative disease, Glomerulonephritis - sparse hair - telangiectasis, genetic disorder and Varicose veins.
How long is the SOX18 protein?
The Homo sapiens SOX18 protein (UniProt P35713) is 384 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P35713 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P35713 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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