Hyaluronidase PH-20 (SPAM1)
Homo sapiens — UniProt P38567
Data last refreshed: (UniProt release unknown)
Key facts
Hyaluronidase PH-20 (SPAM1) is a protein from Homo sapiens identified by UniProt accession P38567, 509 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: P38567; gene symbol SPAM1.
- Organism: Homo sapiens.
- Length: 509 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, cutaneous melanoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hyaluronidase PH-20 |
|---|---|
| UniProt accession | P38567 |
| Gene | SPAM1 |
| Organism | Homo sapiens |
| Length | 509 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.23
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.16
- squamous cell lung carcinoma · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- neoplasm · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- azoospermia · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P38567-F1 | alphafold | PREDICTED | 88.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P38567.
Amino-acid sequence (509 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAM1?
The strongest Open Targets associations for SPAM1 are lung adenocarcinoma, cutaneous melanoma, breast adenocarcinoma, glioblastoma multiforme and squamous cell lung carcinoma.
How long is the SPAM1 protein?
The Homo sapiens SPAM1 protein (UniProt P38567) is 509 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P38567 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P38567 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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