Transcription factor SOX-3 (SOX3)
Homo sapiens — UniProt P41225
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-3 (SOX3) is a protein from Homo sapiens identified by UniProt accession P41225, 446 residues long. MolForge cross-references it against 0 known binders and 271 disease associations.
- UniProt accession: P41225; gene symbol SOX3.
- Organism: Homo sapiens.
- Length: 446 amino acids.
- Top disease associations (Open Targets): Non-acquired isolated growth hormone deficiency, panhypopituitarism and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-3 |
|---|---|
| UniProt accession | P41225 |
| Gene | SOX3 |
| Organism | Homo sapiens |
| Length | 446 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (271)
Diseases linked to this target (Open Targets).
- Non-acquired isolated growth hormone deficiency · score 0.73
- panhypopituitarism · score 0.68
- neurodegenerative disease · score 0.55
- X-linked intellectual disability with isolated growth hormone deficiency · score 0.46
- 46,XX testicular disorder of sex development · score 0.38
- Septo-optic dysplasia · score 0.37
- X-linked congenital generalized hypertrichosis · score 0.37
- Abnormal brain morphology · score 0.27
- essential hypertension · score 0.23
- familial isolated hypoparathyroidism due to agenesis of parathyroid gland · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P41225-F1 | alphafold | PREDICTED | 56.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P41225.
Amino-acid sequence (446 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX3?
The strongest Open Targets associations for SOX3 are Non-acquired isolated growth hormone deficiency, panhypopituitarism, neurodegenerative disease, X-linked intellectual disability with isolated growth hormone deficiency and 46,XX testicular disorder of sex development.
How long is the SOX3 protein?
The Homo sapiens SOX3 protein (UniProt P41225) is 446 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P41225 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P41225 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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