About Carbonic anhydrase 7
Carbonic anhydrase 7 (CA7) is a protein
from Homo sapiens identified by UniProt accession
P43166, 264 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Carbonic anhydrase 7 |
|---|
| UniProt accession | P43166 |
|---|
| Gene | CA7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 264 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (55)
Diseases linked to this target (Open Targets).
- glaucoma · score 0.49
- open-angle glaucoma · score 0.46
- epilepsy · score 0.44
- altitude sickness · score 0.38
- hypoxia · score 0.37
- neurodegenerative disease · score 0.32
- neuroinflammatory disorder · score 0.18
- colorectal carcinoma · score 0.08
- diastolic blood pressure · score 0.08
- obstructive sleep apnea · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43166-F1 | alphafold | PREDICTED | 97.03 | — |
Amino-acid sequence (264 residues)
MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE LSYEACMSLS ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG KKHDVGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAASAP DGLAVVGVFL ETGDEHPSMN RLTDALYMVR FKGTKAQFSC FNPKCLLPAS RHYWTYPGSL TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER IHMVNNFRPP QPLKGRVVKA SFRA
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