About Tyrosine-protein kinase SYK
Tyrosine-protein kinase SYK (SYK) is a protein
from Homo sapiens identified by UniProt accession
P43405, 635 residues long.
MolForge cross-references it against 0 known binders and
766 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase SYK |
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| UniProt accession | P43405 |
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| Gene | SYK |
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| Organism | Homo sapiens |
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| Length | 635 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (766)
Diseases linked to this target (Open Targets).
- cutaneous Leishmaniasis · score 0.57
- Immunodeficiency · score 0.57
- Decreased circulating antibody level · score 0.56
- immunodeficiency 82 with systemic inflammation · score 0.56
- autoimmune thrombocytopenic purpura · score 0.55
- Thrombocytopenia · score 0.53
- colitis · score 0.49
- platelet count · score 0.49
- Skin rash · score 0.48
- monocyte count · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43405-F1 | alphafold | PREDICTED | 84.02 | — |
Amino-acid sequence (635 residues)
MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN
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